Ontology highlight
ABSTRACT:
SUBMITTER: Bomar MG
PROVIDER: S-EPMC2841503 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Molecular cell 20100201 3
Translesion synthesis is an essential cell survival strategy to promote replication after DNA damage. The accumulation of Y family polymerases (pol) iota and Rev1 at the stalled replication machinery is mediated by the ubiquitin-binding motifs (UBMs) of the polymerases and enhanced by PCNA monoubiquitination. We report the solution structures of the C-terminal UBM of human pol iota and its complex with ubiquitin. Distinct from other ubiquitin-binding domains, the UBM binds to the hydrophobic sur ...[more]