Molecular mechanism of the sweet taste enhancers.
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ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC2842058 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Molecular mechanism of the sweet taste enhancers.
Zhang Feng F Klebansky Boris B Fine Richard M RM Liu Haitian H Xu Hong H Servant Guy G Zoller Mark M Tachdjian Catherine C Li Xiaodong X
Proceedings of the National Academy of Sciences of the United States of America 20100219 10
Positive allosteric modulators of the human sweet taste receptor have been developed as a new way of reducing dietary sugar intake. Besides their potential health benefit, the sweet taste enhancers are also valuable tool molecules to study the general mechanism of positive allosteric modulations of T1R taste receptors. Using chimeric receptors, mutagenesis, and molecular modeling, we reveal how these sweet enhancers work at the molecular level. Our data argue that the sweet enhancers follow a si ...[more]
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