Ontology highlight
ABSTRACT:
SUBMITTER: Koonpaew S
PROVIDER: S-EPMC2118069 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Koonpaew Surapong S Shen Shudan S Flowers Lawrence L Zhang Weiguo W
The Journal of experimental medicine 20051227 1
Engagement of the T cell receptor for antigen (TCR) induces formation of signaling complexes mediated through the transmembrane adaptor protein, the linker for activation of T cells (LAT). LAT plays an important role in T cell development, activation, and homeostasis. A knock-in mutation at Tyr136, which is the phospholipase C (PLC)-gamma1-binding site in LAT, leads to a severe autoimmune disease in mice. In this study, we show that CD4+CD25+ T reg cells that expressed Foxp3 transcription factor ...[more]