Ontology highlight
ABSTRACT:
SUBMITTER: Orr MT
PROVIDER: S-EPMC2842453 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Orr Mark T MT Murphy William J WJ Lanier Lewis L LL
Nature immunology 20100228 4
Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self MHC class I are hyporesponsive. Here we show that contrary to the licensing hypothesis, unlicensed NK cells were the main mediators of NK cell-mediated control of mouse cytomegalovirus infection in vivo. Depletion of unlicensed NK cells impaired c ...[more]