Ontology highlight
ABSTRACT:
SUBMITTER: Adams NM
PROVIDER: S-EPMC6614060 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Adams Nicholas M NM Geary Clair D CD Santosa Endi K EK Lumaquin Dianne D Le Luduec Jean-Benoît JB Sottile Rosa R van der Ploeg Kattria K Hsu Joy J Whitlock Benjamin M BM Jackson Benjamin T BT Weizman Orr-El OE Huse Morgan M Hsu Katharine C KC Sun Joseph C JC
Immunity 20190515 6
The process of affinity maturation, whereby T and B cells bearing antigen receptors with optimal affinity to the relevant antigen undergo preferential expansion, is a key feature of adaptive immunity. Natural killer (NK) cells are innate lymphocytes capable of "adaptive" responses after cytomegalovirus (CMV) infection. However, whether NK cells are similarly selected on the basis of their avidity for cognate ligand is unknown. Here, we showed that NK cells with the highest avidity for the mouse ...[more]