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Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium.


ABSTRACT: Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly active against S. aureus.

SUBMITTER: Manzo E 

PROVIDER: S-EPMC2842915 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature

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Aromatic cyclic peroxides and related keto-compounds from the Plakortis sp. component of a sponge consortium.

Manzo Emiliano E   Ciavatta M Letizia ML   Melck Dominique D   Schupp Peter P   de Voogd Nicole N   Gavagnin Margherita M  

Journal of natural products 20090801 8


Six unreported aromatic compounds, 1-6, were isolated, along with the known compounds dehydrocurcuphenol and manoalide, from a sample of Plakortis sp., which was the main component of a Pacific sponge consortium. The new molecules were chemically characterized by spectroscopic methods. Compounds 1-4 contain a six-membered cyclic peroxide, whereas 5 and 6 display a terminal methyl ketone. The new metabolites were tested for antifungal and antibacterial properties. Compounds 1 and 4 were weakly ac  ...[more]

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