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Cyclic Bis-1,3-dialkylpyridiniums from the sponge Haliclona sp.

ABSTRACT: Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

SUBMITTER: Lee Y 

PROVIDER: S-EPMC3475278 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Cyclic Bis-1,3-dialkylpyridiniums from the sponge Haliclona sp.

Lee Yoonyeong Y   Jang Kyoung Hwa KH   Jeon Ju-Eun JE   Yang Woo-Young WY   Sim Chung J CJ   Oh Ki-Bong KB   Shin Jongheon J  

Marine drugs 20120924 9

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on thei  ...[more]

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