Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC3475278 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Marine drugs 20120924 9
Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on thei ...[more]