Ontology highlight
ABSTRACT:
SUBMITTER: Mille F
PROVIDER: S-EPMC2844407 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Mille Frédéric F Thibert Chantal C Fombonne Joanna J Rama Nicolas N Guix Catherine C Hayashi Hideki H Corset Véronique V Reed John C JC Mehlen Patrick P
Nature cell biology 20090524 6
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogenic activity, Shh is also a survival factor. Along this line, Ptc has been shown to function as a dependence receptor; it induces apoptosis in the absence of Shh, whereas its pro-apoptotic activity is blocked in the presence of Shh. Here we show that, in the absence of its ligand, Ptc interacts with the adaptor protein DRAL (downregulated in rhabdomy ...[more]