Ontology highlight
ABSTRACT:
SUBMITTER: Estornes Y
PROVIDER: S-EPMC3422471 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Estornes Y Y Toscano F F Virard F F Jacquemin G G Pierrot A A Vanbervliet B B Bonnin M M Lalaoui N N Mercier-Gouy P P Pachéco Y Y Salaun B B Renno T T Micheau O O Lebecque S S
Cell death and differentiation 20120316 9
Toll-like receptor 3 (TLR3) is a pattern-recognition receptor known to initiate an innate immune response when stimulated by double-stranded RNA (dsRNA). Components of TLR3 signaling, including TIR domain-containing adapter inducing IFN-α (TRIF), have been demonstrated to contribute to dsRNA-induced cell death through caspase-8 and receptor interacting protein (RIP)1 in various human cancer cells. We provide here a detailed analysis of the caspase-8 activating machinery triggered in response to ...[more]