Ontology highlight
ABSTRACT:
SUBMITTER: Yamtich J
PROVIDER: S-EPMC2846199 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20090723 5
The X family of DNA polymerases in eukaryotic cells consists of terminal transferase and DNA polymerases beta, lambda, and mu. These enzymes have similar structural portraits, yet different biochemical properties, especially in their interactions with DNA. None of these enzymes possesses a proofreading subdomain, and their intrinsic fidelity of DNA synthesis is much lower than that of a polymerase that functions in cellular DNA replication. In this review, we discuss the similarities and differe ...[more]