Ontology highlight
ABSTRACT:
SUBMITTER: Shea KL
PROVIDER: S-EPMC2846417 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Shea Kelly L KL Xiang Wanyi W LaPorta Vincent S VS Licht Jonathan D JD Keller Charles C Basson M Albert MA Brack Andrew S AS
Cell stem cell 20100201 2
Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear. The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool. By using a lineage tracing approach, we show that after injury, quiescent adult Pax7(+) cells enter the cell cycle; a subpopulation returns to quiescence to replenish the satellite cell comp ...[more]