Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC2846637 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Yang Xingyuan X Lu Xin X Liu Jun J
FEBS letters 20100118 5
The comparative gene identification-58 (CGI-58) gene, mutations of which are linked to Chanarin-Dorfman syndrome, encodes a protein of the alpha/beta hydrolase domain subfamily. We report here a new alternative splicing isoform of the murine CGI-58 gene, termed mCGI-58S. Sequence comparison indicates the lack of second and third exons in this cDNA variant. While the full-length protein displayed perilipin-dependent localization to lipid droplets, mCGI-58S showed a predominant cytoplasmic stainin ...[more]