Ontology highlight
ABSTRACT:
SUBMITTER: Kelly RC
PROVIDER: S-EPMC2847429 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Kelly Robert C RC Bolitho Megan E ME Higgins Douglas A DA Lu Wenyun W Ng Wai-Leung WL Jeffrey Philip D PD Rabinowitz Joshua D JD Semmelhack Martin F MF Hughson Frederick M FM Bassler Bonnie L BL
Nature chemical biology 20091018 12
Vibrio cholerae, the bacterium that causes the disease cholera, controls virulence factor production and biofilm development in response to two extracellular quorum-sensing molecules, called autoinducers. The strongest autoinducer, called CAI-1 (for cholera autoinducer-1), was previously identified as (S)-3-hydroxytridecan-4-one. Biosynthesis of CAI-1 requires the enzyme CqsA. Here, we determine the CqsA reaction mechanism, identify the CqsA substrates as (S)-2-aminobutyrate and decanoyl coenzym ...[more]