Ontology highlight
ABSTRACT:
SUBMITTER: Perez LJ
PROVIDER: S-EPMC3798069 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20121108 22
Quorum sensing is a mechanism of chemical communication among bacteria that enables collective behaviors. In V. cholerae, the etiological agent of the disease cholera, quorum sensing controls group behaviors including virulence factor production and biofilm formation. The major V. cholerae quorum-sensing system consists of the extracellular signal molecule called CAI-1 and its cognate membrane bound receptor called CqsS. Here, the ligand binding activity of CqsS is probed with structural analogu ...[more]