Ontology highlight
ABSTRACT:
SUBMITTER: Pratt WD
PROVIDER: S-EPMC2849326 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Clinical and vaccine immunology : CVI 20100224 4
Ebola viruses are highly pathogenic viruses that cause outbreaks of hemorrhagic fever in humans and other primates. To meet the need for a vaccine against the several types of Ebola viruses that cause human diseases, we developed a multivalent vaccine candidate (EBO7) that expresses the glycoproteins of Zaire ebolavirus (ZEBOV) and Sudan ebolavirus (SEBOV) in a single complex adenovirus-based vector (CAdVax). We evaluated our vaccine in nonhuman primates against the parenteral and aerosol routes ...[more]