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Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals.

ABSTRACT: Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice.

SUBMITTER: Clark JJ

PROVIDER: S-EPMC2849934 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals.

Clark Jeremy J JJ Sandberg Stefan G SG Wanat Matthew J MJ Gan Jerylin O JO Horne Eric A EA Hart Andrew S AS Akers Christina A CA Parker Jones G JG Willuhn Ingo I Martinez Vicente V Evans Scott B SB Stella Nephi N Phillips Paul E M PE

Nature methods 20091227 2

Neurotransmission operates on a millisecond timescale but is changed by normal experience or neuropathology over days to months. Despite the importance of long-term neurotransmitter dynamics, no technique exists to track these changes in a subject from day to day over extended periods of time. Here we describe and characterize a microsensor that can detect the neurotransmitter dopamine with subsecond temporal resolution over months in vivo in rats and mice. ...[more]

PMID: 20037591

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