Ontology highlight
ABSTRACT:
SUBMITTER: Cui CY
PROVIDER: S-EPMC2850388 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
PloS one 20100401 4
The mouse hair coat comprises protective "primary" and thermo-regulatory "secondary" hairs. Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair. We report that Dickkopf 4 (Dkk4), a Wnt antagonist, affects an auxiliary pathway for Eda-independent development of secondary hair. A Dkk4 transgene in wild-type mice had no effect on primary hair, but secondary hairs were severely malformed. Dkk4 action on secondary hair ...[more]