Ontology highlight
ABSTRACT:
SUBMITTER: Kang SG
PROVIDER: S-EPMC2850418 | biostudies-literature | 2010 Jan-Mar
REPOSITORIES: biostudies-literature
Kang Sang-Gyun SG Roh Yu Mi YM Kang Mi Lan ML Kim Yong-Sun YS Yoo Han Sang HS
Prion 20100115 1
Prion diseases, which are called transmissible spongiform encephalopathies (TSEs), comprise a group of fatal infectious neurodegenerative disorders. Investigation of prion strains and generation of species dependent TSE model are necessary to understand pathogenesis of the disease. To establish a BSE-specific in vitro cell culture model, N2a and GT1 mouse neuronal cell lines were generated to express the bovine prion protein by transfection of the bovine prion gene (Prnp). In addition, the endog ...[more]