Ontology highlight
ABSTRACT:
SUBMITTER: Morange PE
PROVIDER: S-EPMC2850428 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Morange Pierre-Emmanuel PE Bezemer Irene I Saut Noémie N Bare Lance L Burgos Gwenaelle G Brocheton Jessy J Durand Hervé H Biron-Andreani Christine C Schved Jean-Francois JF Pernod Gilles G Galan Pilar P Drouet Ludovic L Zelenika Diana D Germain Marine M Nicaud Viviane V Heath Simon S Ninio Ewa E Delluc Aurélien A Münzel Thomas T Zeller Tanja T Brand-Herrmann Stefan-Martin SM Alessi Marie-Christine MC Tiret Laurence L Lathrop Mark M Cambien François F Blankenberg Stefan S Emmerich Joseph J Trégouët David-Alexandre DA Rosendaal Frits R FR
American journal of human genetics 20100311 4
To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confiden ...[more]