Dataset Information

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

ABSTRACT: We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

SUBMITTER: Thye T

PROVIDER: S-EPMC4975513 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Thye Thorsten T Vannberg Fredrik O FO Wong Sunny H SH Owusu-Dabo Ellis E Osei Ivy I Gyapong John J Sirugo Giorgio G Sisay-Joof Fatou F Enimil Anthony A Chinbuah Margaret A MA Floyd Sian S Warndorff David K DK Sichali Lifted L Malema Simon S Crampin Amelia C AC Ngwira Bagrey B Teo Yik Y YY Small Kerrin K Rockett Kirk K Kwiatkowski Dominic D Fine Paul E PE Hill Philip C PC Newport Melanie M Lienhardt Christian C Adegbola Richard A RA Corrah Tumani T Ziegler Andreas A Morris Andrew P AP Meyer Christian G CG Horstmann Rolf D RD Hill Adrian V S AVS

Nature genetics 20100808 9

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibriu ...[more]

PMID: 20694014

Dataset Information

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Publications

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
| S-EPMC3354739 | biostudies-literature

A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
| S-EPMC3298111 | biostudies-literature

Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14.
| S-EPMC5665761 | biostudies-literature

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
| S-EPMC3136364 | biostudies-literature

Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25.
| S-EPMC4375409 | biostudies-literature

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.
| S-EPMC3227560 | biostudies-literature

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.
| S-EPMC3983781 | biostudies-literature

Genome-wide association study identifies a possible susceptibility locus for endometrial cancer.
| S-EPMC3372671 | biostudies-literature

A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1.
| S-EPMC2850428 | biostudies-literature

Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.
| S-EPMC2650328 | biostudies-literature