Ontology highlight
ABSTRACT:
SUBMITTER: Izumikawa T
PROVIDER: S-EPMC2852958 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100217 16
We have revealed that in Caenorhabditis elegans, non-sulfated chondroitin is required for normal cell division and cytokinesis at an early developmental stage, whereas heparan sulfate is essential for embryonic morphogenesis in the later stages of development. To clarify the roles of chondroitin sulfate and heparan sulfate in early embryogenesis in mammals, we generated glucuronyltransferase-I (GlcAT-I) knock-out mice by gene targeting. GlcAT-I is an enzyme required for the synthesis of both cho ...[more]