Ontology highlight
ABSTRACT:
SUBMITTER: Lepretre F
PROVIDER: S-EPMC2853126 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Leprêtre F F Villenet C C Quief S S Nibourel O O Jacquemin C C Troussard X X Jardin F F Gibson F F Kerckaert J P JP Roumier C C Figeac M M
Nucleic acids research 20100113 7
Array-based comparative genomic hybridization (aCGH) is a powerful tool to detect genomic imbalances in the human genome. The analysis of aCGH data sets has revealed the existence of a widespread technical artifact termed as 'waves', characterized by an undulating data profile along the chromosome. Here, we describe the development of a novel noise-reduction algorithm, waves aCGH correction algorithm (WACA), based on GC content and fragment size correction. WACA efficiently removes the wave arti ...[more]