Ontology highlight
ABSTRACT:
SUBMITTER: Hill JW
PROVIDER: S-EPMC2854520 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cell metabolism 20100401 4
Circulating leptin and insulin convey information regarding energy stores to the central nervous system, particularly the hypothalamus. Hypothalamic pro-opiomelanocortin (POMC) neurons regulate energy balance and glucose homeostasis and express leptin and insulin receptors. However, the physiological significance of concomitant leptin and insulin action on POMC neurons remains to be established. Here, we show that mice lacking both leptin and insulin receptors in POMC neurons (Pomc-Cre, Lepr(flo ...[more]