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5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

ABSTRACT: Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished the anti-diabetic effects of meta-chlorophenylpiperazine (a 5-HT(2C)R agonist); these effects were restored when 5-HT(2C)Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivity and glucose homeostasis in the liver.

SUBMITTER: Xu Y

PROVIDER: S-EPMC3059249 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature

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5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Xu Yong Y Berglund Eric D ED Sohn Jong-Woo JW Holland William L WL Chuang Jen-Chieh JC Fukuda Makoto M Rossi Jari J Williams Kevin W KW Jones Juli E JE Zigman Jeffrey M JM Lowell Bradford B BB Scherer Philipp E PE Elmquist Joel K JK

Nature neuroscience 20101031 12

Mice lacking 5-HT 2C receptors (5-HT(2C)Rs) displayed hepatic insulin resistance, a phenotype normalized by re-expression of 5-HT(2C)Rs only in pro-opiomelanocortin (POMC) neurons. 5-HT(2C)R deficiency also abolished the anti-diabetic effects of meta-chlorophenylpiperazine (a 5-HT(2C)R agonist); these effects were restored when 5-HT(2C)Rs were re-expressed in POMC neurons. Our findings indicate that 5-HT(2C)Rs expressed by POMC neurons are physiologically relevant regulators of insulin sensitivi ...[more]

PMID: 21037584

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