Ontology highlight
ABSTRACT:
SUBMITTER: Huang KS
PROVIDER: S-EPMC2854833 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Huang Kevin S KS Carrasco Nicolas N Pfund Emmanuel E Strobel Scott A SA
Biochemistry 20080802 34
The ribosomal peptidyl transferase is a biologically essential catalyst responsible for protein synthesis. The reaction is expected to proceed through a transition state approaching tetrahedral geometry with a specific chirality. To establish that stereospecificity, we synthesized two diastereomers of a transition state inhibitor with mimics for each of the four ligands around the reactive chiral center. Preferential binding of the inhibitor that mimics a transition state with S chirality establ ...[more]