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Structural insights into RNA interference.

ABSTRACT: Virtually all animals and plants utilize small RNA molecules to control protein expression during different developmental stages and in response to viral infection. Structural and mechanistic studies have begun to illuminate three fundamental aspects of these pathways: small RNA biogenesis, formation of RNA-induced silencing complexes (RISCs), and targeting of complementary mRNAs. Here we review exciting recent progress in understanding how regulatory RNAs are produced and how they trigger specific destruction of mRNAs during RNA interference (RNAi).

SUBMITTER: Sashital DG

PROVIDER: S-EPMC2855239 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Structural insights into RNA interference.

Sashital Dipali G DG Doudna Jennifer A JA

Current opinion in structural biology 20100105 1

Virtually all animals and plants utilize small RNA molecules to control protein expression during different developmental stages and in response to viral infection. Structural and mechanistic studies have begun to illuminate three fundamental aspects of these pathways: small RNA biogenesis, formation of RNA-induced silencing complexes (RISCs), and targeting of complementary mRNAs. Here we review exciting recent progress in understanding how regulatory RNAs are produced and how they trigger speci ...[more]

PMID: 20053548

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