Ontology highlight
ABSTRACT:
SUBMITTER: Rainey MA
PROVIDER: S-EPMC2856533 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Rainey Mark A MA George Manju M Ying GuoGuang G Akakura Reiko R Burgess Daniel J DJ Siefker Ed E Bargar Tom T Doglio Lynn L Crawford Susan E SE Todd Gordon L GL Govindarajan Venkatesh V Hess Rex A RA Band Vimla V Naramura Mayumi M Band Hamid H
BMC developmental biology 20100402
<h4>Background</h4>The C-terminal Eps15 homology domain-containing protein 1 (EHD1) is ubiquitously expressed and regulates the endocytic trafficking and recycling of membrane components and several transmembrane receptors. To elucidate the function of EHD1 in mammalian development, we generated Ehd1-/- mice using a Cre/loxP system.<h4>Results</h4>Both male and female Ehd1-/- mice survived at sub-Mendelian ratios. A proportion of Ehd1-/- mice were viable and showed smaller size at birth, which c ...[more]