RNF216 is essential for spermatogenesis and male fertility†.
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ABSTRACT:
SUBMITTER: Melnick AF
PROVIDER: S-EPMC6698654 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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RNF216 is essential for spermatogenesis and male fertility†.
Melnick Ashley F AF Gao Yuen Y Liu Jiali J Ding Deqiang D Predom Alicia A Kelly Catherine C Hess Rex A RA Chen Chen C
Biology of reproduction 20190501 5
Ring finger protein 216 (RNF216) belongs to the RING family of E3 ubiquitin ligases that are involved in cellular protein degradation. Mutations in human Rnf216 gene have been identified in Gordon Holmes syndrome, which is defined by ataxia, dementia, and hypogonadotropism. However, the gene function of Rnf216 in mammalian species remains unknown. Here, we show that targeted deletion of Rnf216 in mice results in disruption in spermatogenesis and male infertility. RNF216 is not required for femal ...[more]
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