Ontology highlight
ABSTRACT:
SUBMITTER: Lieberman-Aiden E
PROVIDER: S-EPMC2858594 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Lieberman-Aiden Erez E van Berkum Nynke L NL Williams Louise L Imakaev Maxim M Ragoczy Tobias T Telling Agnes A Amit Ido I Lajoie Bryan R BR Sabo Peter J PJ Dorschner Michael O MO Sandstrom Richard R Bernstein Bradley B Bender M A MA Groudine Mark M Gnirke Andreas A Stamatoyannopoulos John J Mirny Leonid A LA Lander Eric S ES Dekker Job J
Science (New York, N.Y.) 20091001 5950
We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1 megabase. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is characterized by the spatial segregation of open and cl ...[more]