Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC6402586 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Xu Zhixiong Z Wei Gang G Chepelev Iouri I Zhao Keji K Felsenfeld Gary G
Nature structural & molecular biology 20110220 3
Insulin (INS) synthesis and secretion from pancreatic β-cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb away. This interaction is elevated by glucose and accompanied by increases in SYT8 expression. Inactivation of the INS promoter by promoter-targeting siRNA reduces SYT8 gene expression. SYT8-INS interaction a ...[more]