Ontology highlight
ABSTRACT:
SUBMITTER: Qian K
PROVIDER: S-EPMC2860721 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Qian Keduo K Kuo Reen-Yun RY Chen Chin-Ho CH Huang Li L Morris-Natschke Susan L SL Lee Kuo-Hsiung KH
Journal of medicinal chemistry 20100401 8
In our continuing study of triterpene derivatives as potent anti-HIV agents, different C-3 conformationally restricted betulinic acid (BA, 1) derivatives were designed and synthesized in order to explore the conformational space of the C-3 pharmacophore. 3-O-Monomethylsuccinyl-betulinic acid (MSB) analogues were also designed to better understand the contribution of the C-3' dimethyl group of bevirimat (2), the first-in-class HIV maturation inhibitor, which is currently in phase IIb clinical tri ...[more]