Ontology highlight
ABSTRACT:
SUBMITTER: Qian K
PROVIDER: S-EPMC3478670 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Qian Keduo K Bori Ibrahim D ID Chen Chin-Ho CH Huang Li L Lee Kuo-Hsiung KH
Journal of medicinal chemistry 20120914 18
In a continuing study of bevirimat (2), the anti-HIV-maturation clinical trials agent, 28 new betulinic acid (BA, 1) derivatives were designed and synthesized. Among these compounds, 17, with a C-28 MEM ester moiety, and 22, with a C-28 ethyl hexanoate, increased the anti-HIV replication activity compared with 2 by 2-fold while compounds 40, 41, 48, and 49, with C-28 piperazine or piperidine amide substitutions, increased the activity by 3- to 15-fold. The best new compound, 41, exhibited an ant ...[more]