Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder.

ABSTRACT:

Background

Inhibitory control or regulatory difficulties have been explored in major depressive disorder (MDD) but typically in the context of affectively salient information. Inhibitory control is addressed specifically by using a task devoid of affectively-laden stimuli, to disentangle the effects of altered affect and altered inhibitory processes in MDD.

Methods

Twenty MDD and 22 control volunteer participants matched by age and gender completed a contextual inhibitory control task, the Parametric Go/No-go (PGNG) task during functional magnetic resonance imaging. The PGNG includes three levels of difficulty, a typical continuous performance task and two progressively more difficult versions including Go/No-go hit and rejection trials. After this test, 15 of 20 MDD patient

SUBMITTER: Langenecker SA 

PROVIDER: S-EPMC2860742 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature