A global assembly line for cyanobactins.
Ontology highlight
ABSTRACT:
SUBMITTER: Donia MS
PROVIDER: S-EPMC2862271 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Publications
A global assembly line for cyanobactins.
Donia Mohamed S MS Ravel Jacques J Schmidt Eric W EW
Nature chemical biology 20080420 6
More than 100 cyclic peptides harboring heterocyclized residues are known from marine ascidians, sponges and different genera of cyanobacteria. Here, we report an assembly line responsible for the biosynthesis of these diverse peptides, now called cyanobactins, both in symbiotic and free-living cyanobacteria. By comparing five new cyanobactin biosynthetic clusters, we produced the prenylated antitumor preclinical candidate trunkamide in Escherichia coli culture using genetic engineering. ...[more]
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