Ontology highlight
ABSTRACT:
SUBMITTER: Shah AK
PROVIDER: S-EPMC2862389 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Shah Abhishek K AK Tioleco Nina M NM Nolan Karen K Locker Joseph J Groh Katherine K Villa Catalina C Stopkova Pavla P Pedrosa Erika E Lachman Herbert M HM
Neuroscience letters 20100325 2
Copy number variants (CNVs) affecting the neurexin 1 (NRXN1) gene have been found in a subgroup of patients with schizophrenia (SZ). NRXN1 expression is complex, with multiple alternative splice forms generated from two major transcripts; NRXN1alpha and NRXN1beta. The majority of CNVs in SZ are deletions affecting the proximal NRXN1alpha exons and promoter region. Rare chromosomal events are useful in understanding the genetic basis of complex psychiatric disorders since affected genes become fe ...[more]