Ontology highlight
ABSTRACT:
SUBMITTER: Fontanellas A
PROVIDER: S-EPMC2862529 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Fontanellas Antonio A Hervás-Stubbs Sandra S Mauleón Itsaso I Dubrot Juan J Mancheño Uxua U Collantes María M Sampedro Ana A Unzu Carmen C Alfaro Carlos C Palazón Asis A Smerdou Cristian C Benito Alberto A Prieto Jesús J Peñuelas Iván I Melero Ignacio I
Molecular therapy : the journal of the American Society of Gene Therapy 20100119 4
Repeated administration of gene therapies is hampered by host immunity toward vectors and transgenes. Attempts to circumvent antivector immunity include pharmacological immunosuppression or alternating different vectors and vector serotypes with the same transgene. Our studies show that B-cell depletion with anti-CD20 monoclonal antibody and concomitant T-cell inhibition with clinically available drugs permits repeated liver gene transfer to a limited number of nonhuman primates with recombinant ...[more]