Ontology highlight
ABSTRACT:
SUBMITTER: Gopal S
PROVIDER: S-EPMC2863221 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Gopal Sandeep S Bober Adam A Whiteford James R JR Multhaupt Hinke A B HA Yoneda Atsuko A Couchman John R JR
The Journal of biological chemistry 20100212 19
Fibroblasts null for the transmembrane proteoglycan, syndecan-4, have an altered actin cytoskeleton, compared with matching wild-type cells. They do not organize alpha-smooth muscle actin into bundles, but will do so when full-length syndecan-4 is re-expressed. This requires the central V region of the core protein cytoplasmic domain, though not interactions with PDZ proteins. A second key requirement is multiple heparan sulfate chains. Mutant syndecan-4 with no chains, or only one chain, failed ...[more]