Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida K
PROVIDER: S-EPMC4139068 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Yoshida Keisuke K Yang Bo B Yang Weizhun W Zhang Zeren Z Zhang Jicheng J Huang Xuefei X
Angewandte Chemie (International ed. in English) 20140630 34
Despite the ubiquitous presence of proteoglycans in mammalian systems, methodologies to synthesize this class of glycopeptides with homogeneous glycans are not well developed. Herein, we report the first synthesis of a glycosaminoglycan family glycopeptide containing two different heparan sulfate chains, namely the extracellular domain of syndecan-3. With the large size and tremendous structural complexity of these molecules, multiple unexpected obstacles were encountered during the synthesis, i ...[more]