Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.
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ABSTRACT:
SUBMITTER: Sugi T
PROVIDER: S-EPMC2863409 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
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Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.
Sugi Tatsuki T Kato Kentaro K Kobayashi Kyosuke K Watanabe Shumpei S Kurokawa Hitomi H Gong Haiyan H Pandey Kishor K Takemae Hitoshi H Akashi Hiroomi H
Eukaryotic cell 20100219 4
Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility. ...[more]
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