Ontology highlight
ABSTRACT:
SUBMITTER: Ndungu JM
PROVIDER: S-EPMC2866085 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Ndungu John M JM Lu Yang J YJ Zhu Shijun S Yang Chao C Wang Xu X Chen Georgia G Shin Dong M DM Snyder James P JP Shoji Mamoru M Sun Aiming A
Journal of medicinal chemistry 20100401 8
We previously reported a novel drug delivery system, drug-linker-Phe-Phe-Arg-methylketone (FFR-mk)-factor VIIa (fVIIa). The method utilizes tissue factor (TF), which is aberrantly and abundantly expressed on many cancer cells. The advantage of this delivery system is its ability to furnish a potent anticancer drug specifically to the tumor vasculature and cancer cells. In this paper, we describe the synthesis of paclitaxel (PTX)-Phe-Phe-Arg-chloromethyl ketone (FFR-ck), followed by coupling with ...[more]