Ontology highlight
ABSTRACT:
SUBMITTER: Olson DP
PROVIDER: S-EPMC2867727 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Olson David P DP Pulinilkunnil Thomas T Cline Gary W GW Shulman Gerald I GI Lowell Bradford B BB
Proceedings of the National Academy of Sciences of the United States of America 20100405 16
Deletion of acetyl CoA carboxylase-2 (Acc2) reportedly causes leanness in the setting of hyperphagia. To determine the cellular basis for these effects, we generated a mouse model in which Acc2 can be selectively deleted by the action of Cre recombinase. Deletion of Acc2 from skeletal muscle, the predominant site of Acc2 expression, had no effect on body weight, food intake, or body composition. When Acc2 was inactivated in the germline, Acc2 knockout (Acc2KO) mice displayed no differences in bo ...[more]