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Post-oral sensing of fat increases food intake and attenuates body weight defense.

ABSTRACT: In mammals, changes in weight elicit responses that favor a return to one's previous weight and promote weight stability. It has been hypothesized that palatable sweet and high-fat foods disturb the defense of body weight, leading to weight gain. We find that increasing sweetness or percent calories from fat increases diet palatability but that only increases in nutritive fat content increase caloric intake and body weight. In a mouse model of overfeeding that activates weight defense, high-fat diets, but not sweetened diets, attenuate the defense of body weight, leading to weight gain. The ability of a palatable, high-fat diet to increase food intake does not require tasting or smelling the food. Instead, the direct infusion of a high-fat diet into the stomach increases the ad libitum intake of less palatable, low-fat food. Post-oral sensing of percent calories from fat modulates feeding behavior to alter weight stability.

SUBMITTER: Gallop MR

PROVIDER: S-EPMC8609494 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Post-oral sensing of fat increases food intake and attenuates body weight defense.

Gallop Molly R MR Wilson Victoria C VC Ferrante Anthony W AW

Cell reports 20211001 3

In mammals, changes in weight elicit responses that favor a return to one's previous weight and promote weight stability. It has been hypothesized that palatable sweet and high-fat foods disturb the defense of body weight, leading to weight gain. We find that increasing sweetness or percent calories from fat increases diet palatability but that only increases in nutritive fat content increase caloric intake and body weight. In a mouse model of overfeeding that activates weight defense, high-fat ...[more]

PMID: 34686319

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Dataset Information

Post-oral sensing of fat increases food intake and attenuates body weight defense.

Publications

Post-oral sensing of fat increases food intake and attenuates body weight defense.

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