Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC2867755 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Kumar Amit A Fernandez-Capetillo Oscar O Carrera Ana C AC
Proceedings of the National Academy of Sciences of the United States of America 20100405 16
Class I phosphoinositide 3-kinases are enzymes that generate 3-poly-phosphoinositides at the cell membrane following transmembrane receptor stimulation. Expression of the phosphoinositide 3-kinase beta (PI3Kbeta) isoform, but not its activity, is essential for early embryonic development. Nonetheless, the specific function of PI3Kbeta in the cell remains elusive. Double-strand breaks (DSB) are among the most deleterious lesions for genomic integrity; their repair is required for development. We ...[more]