Ontology highlight
ABSTRACT:
SUBMITTER: Rapley EA
PROVIDER: S-EPMC2871592 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Rapley Elizabeth A EA Turnbull Clare C Al Olama Ali Amin AA Dermitzakis Emmanouil T ET Linger Rachel R Huddart Robert A RA Renwick Anthony A Hughes Deborah D Hines Sarah S Seal Sheila S Morrison Jonathan J Nsengimana Jeremie J Deloukas Panagiotis P Rahman Nazneen N Bishop D Timothy DT Easton Douglas F DF Stratton Michael R MR
Nature genetics 20090531 7
We conducted a genome-wide association study for testicular germ cell tumor (TGCT), genotyping 307,666 SNPs in 730 cases and 1,435 controls from the UK and replicating associations in a further 571 cases and 1,806 controls. We found strong evidence for susceptibility loci on chromosome 5 (per allele OR = 1.37 (95% CI = 1.19-1.58), P = 3 x 10(-13)), chromosome 6 (OR = 1.50 (95% CI = 1.28-1.75), P = 10(-13)) and chromosome 12 (OR = 2.55 (95% CI = 2.05-3.19), P = 10(-31)). KITLG, encoding the ligan ...[more]