Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Z
PROVIDER: S-EPMC2876676 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Yuan Zhigang Z Villagra Alejandro A Peng Lirong L Coppola Domenico D Glozak Michele M Sotomayor Eduardo M EM Chen Jiandong J Lane William S WS Seto Edward E
Molecular and cellular biology 20100405 12
The ataxia telangiectasia group D-complementing (ATDC) gene product, also known as TRIM29, is a member of the tripartite motif (TRIM) protein family. ATDC has been proposed to form homo- or heterodimers and to bind nucleic acids. In cell cultures, ATDC expression leads to rapid growth and resistance to ionizing radiation (IR), whereas silencing of ATDC expression decreases growth rates and increases sensitivity to IR. Although ATDC is overexpressed in many human cancers, the biological significa ...[more]