Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC3961828 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Wang Lidong L Yang Huibin H Palmbos Phillip L PL Ney Gina G Detzler Taylor Ann TA Coleman Dawn D Leflein Jacob J Davis Mary M Zhang Min M Tang Wenhua W Hicks J Kevin JK Helchowski Corey M CM Prasad Jayendra J Lawrence Theodore S TS Xu Liang L Yu Xiaochun X Canman Christine E CE Ljungman Mats M Simeone Diane M DM
Cancer research 20140127 6
Pancreatic ductal adenocarcinoma (PDAC) is characterized by therapeutic resistance for which the basis is poorly understood. Here, we report that the DNA and p53-binding protein ATDC/TRIM29, which is highly expressed in PDAC, plays a critical role in DNA damage signaling and radioresistance in pancreatic cancer cells. Ataxia-telangiectasia group D-associated gene (ATDC) mediated resistance to ionizing radiation in vitro and in vivo in mouse xenograft assays. ATDC was phosphorylated directly by M ...[more]