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Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.

ABSTRACT: Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

SUBMITTER: Phelan CM 

PROVIDER: S-EPMC2880167 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.

Phelan Catherine M CM   Tsai Ya-Yu YY   Goode Ellen L EL   Vierkant Robert A RA   Fridley Brooke L BL   Beesley Jonathan J   Chen Xiao Qing XQ   Webb Penelope M PM   Chanock Stephen S   Cramer Daniel W DW   Moysich Kirsten K   Edwards Robert P RP   Chang-Claude Jenny J   Garcia-Closas Montserrat M   Yang Hannah H   Wang-Gohrke Shan S   Hein Rebecca R   Green Adele C AC   Lissowska Jolanta J   Carney Michael E ME   Lurie Galina G   Wilkens Lynne R LR   Ness Roberta B RB   Pearce Celeste Leigh CL   Wu Anna H AH   Van Den Berg David J DJ   Stram Daniel O DO   Terry Kathryn L KL   Whiteman David C DC   Whittemore Alice S AS   DiCioccio Richard A RA   McGuire Valerie V   Doherty Jennifer A JA   Rossing Mary Anne MA   Anton-Culver Hoda H   Ziogas Argyrios A   Hogdall Claus C   Hogdall Estrid E   Krüger Kjaer Susanne S   Blaakaer Jan J   Quaye Lydia L   Ramus Susan J SJ   Jacobs Ian I   Song Honglin H   Pharoah Paul D P PD   Iversen Edwin S ES   Marks Jeffrey R JR   Pike Malcolm C MC   Gayther Simon A SA   Cunningham Julie M JM   Goodman Marc T MT   Schildkraut Joellen M JM   Chenevix-Trench Georgia G   Berchuck Andrew A   Sellers Thomas A TA  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20100201 2

Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-  ...[more]

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