Human chromosome 7: DNA sequence and biology.
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ABSTRACT:
SUBMITTER: Scherer SW
PROVIDER: S-EPMC2882961 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Publications
Human chromosome 7: DNA sequence and biology.
Scherer Stephen W SW Cheung Joseph J MacDonald Jeffrey R JR Osborne Lucy R LR Nakabayashi Kazuhiko K Herbrick Jo-Anne JA Carson Andrew R AR Parker-Katiraee Layla L Skaug Jennifer J Khaja Razi R Zhang Junjun J Hudek Alexander K AK Li Martin M Haddad May M Duggan Gavin E GE Fernandez Bridget A BA Kanematsu Emiko E Gentles Simone S Christopoulos Constantine C CC Choufani Sanaa S Kwasnicka Dorota D Zheng Xiangqun H XH Lai Zhongwu Z Nusskern Deborah D Zhang Qing Q Gu Zhiping Z Lu Fu F Zeesman Susan S Nowaczyk Malgorzata J MJ Teshima Ikuko I Chitayat David D Shuman Cheryl C Weksberg Rosanna R Zackai Elaine H EH Grebe Theresa A TA Cox Sarah R SR Kirkpatrick Susan J SJ Rahman Nazneen N Friedman Jan M JM Heng Henry H Q HH Pelicci Pier Giuseppe PG Lo-Coco Francesco F Belloni Elena E Shaffer Lisa G LG Pober Barbara B Morton Cynthia C CC Gusella James F JF Bruns Gail A P GA Korf Bruce R BR Quade Bradley J BJ Ligon Azra H AH Ferguson Heather H Higgins Anne W AW Leach Natalia T NT Herrick Steven R SR Lemyre Emmanuelle E Farra Chantal G CG Kim Hyung-Goo HG Summers Anne M AM Gripp Karen W KW Roberts Wendy W Szatmari Peter P Winsor Elizabeth J T EJ Grzeschik Karl-Heinz KH Teebi Ahmed A Minassian Berge A BA Kere Juha J Armengol Lluis L Pujana Miguel Angel MA Estivill Xavier X Wilson Michael D MD Koop Ben F BF Tosi Sabrina S Moore Gudrun E GE Boright Andrew P AP Zlotorynski Eitan E Kerem Batsheva B Kroisel Peter M PM Petek Erwin E Oscier David G DG Mould Sarah J SJ Döhner Hartmut H Döhner Konstanze K Rommens Johanna M JM Vincent John B JB Venter J Craig JC Li Peter W PW Mural Richard J RJ Adams Mark D MD Tsui Lap-Chee LC
Science (New York, N.Y.) 20030410 5620
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical genetic data, including 440 chromosome rearrangement breakpoints associated with disease. This approach enabled the discovery of candidate genes f ...[more]