Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC2883162 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Zhang Hengshan H Maguire David D Swarts Steven S Sun Weimin W Yang Shanmin S Wang Wei W Liu Chaomei C Zhang Mei M Zhang Di D Zhang Louie L Zhang Kunzhong K Keng Peter P Zhang Lurong L Okunieff Paul P
Advances in experimental medicine and biology 20090101
The effect of radiation on the mitochondrial genome in vivo is largely unknown. Though mitochondrial DNA (mtDNA) is vital for cellular survival and proliferation, it has little DNA repair machinery compared with nuclear DNA (nDNA). A better understanding of how radiation affects mtDNA should lead to new approaches for radiation protection. We have developed a new system using real-time PCR that sensitively detects the change in copy number of mtDNA compared with nDNA. In each sample, the DNA seq ...[more]