Unknown

Dataset Information

0

Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes.

ABSTRACT: To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case-control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10,870 cases and 73,735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR=0.90, 95% CI=0.86-0.93; P=3.7x10(-8)). The frequency of the risk-lowering allele T is 0.23. Variants in this region were nominally related to lower fasting glucose and HOMA-IR in the MAGIC consortium (P<0.05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance.

SUBMITTER: Qi L 

PROVIDER: S-EPMC2883345 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

To identify type 2 diabetes (T2D) susceptibility loci, we conducted genome-wide association (GWA) scans in nested case-control samples from two prospective cohort studies, including 2591 patients and 3052 controls of European ancestry. Validation was performed in 11 independent GWA studies of 10,870 cases and 73,735 controls. We identified significantly associated variants near RBMS1 and ITGB6 genes at 2q24, best-represented by SNP rs7593730 (combined OR=0.90, 95% CI=0.86-0.93; P=3.7x10(-8)). Th  ...[more]

Similar Datasets

Transcriptomics Systematic Evaluation Of Genes And Genetic Variants Associated With Type 1 Diabetes Susceptibility
2016-02-27 | E-GEOD-77350 | biostudies-arrayexpress
Transcriptomics Systematic Evaluation Of Genes And Genetic Variants Associated With Type 1 Diabetes Susceptibility
2016-02-27 | GSE77350 | GEO
Unknown Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility.
| S-EPMC4799766 | biostudies-literature
Unknown Insulin resistance-associated genetic variants in type 1 diabetes.
| S-EPMC7936951 | biostudies-literature
Unknown Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility.
| S-EPMC3990322 | biostudies-literature
Unknown Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.
| S-EPMC3778915 | biostudies-literature
Unknown Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
| S-EPMC2823809 | biostudies-other
Unknown Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets.
| S-EPMC6198349 | biostudies-literature
Unknown Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
| S-EPMC2866577 | biostudies-literature
Unknown Genetic Variants Associated with Colorectal Adenoma Susceptibility.
| S-EPMC4831735 | biostudies-literature